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Spirohypertone B

CAT: 0804-HY-162599Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162599Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spirohypertone B is a potent Tumor necrosis factor-α (TNF-α) inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D.
UNSPSC
12352005
Target
TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/spirohypertone-b.html
Smiles
O=C1C(C(C2=CC=CC=C2)=O)=C(C)[C@@H](C/C=C(C)/C)C[C@]13C([C@@](C(OC4(C)C)=O)(C/C=C(C)\C)[C@@]4([H])C3)=O
Molecular Formula
C32H38O5
Molecular Weight
502.64
References & Citations
[1]Duan Y, et al. Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures. Acta Pharm Sin B. 2024 Jun;14 (6) :2646-2656.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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