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BAM-12P

CAT: 0804-HY-W019787Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W019787Size:1 Each
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Description
BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].
CAS Number
75513-71-2
UNSPSC
12352209
Target
CXCR; Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bam-12p.html
Solubility
H2O
Smiles
OC(C=C1)=CC=C1C[C@H](N)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C62H97N21O16S
Molecular Weight
1424.63
References & Citations
[1]K Mizuno, et al. A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P) . Biochem Biophys Res Commun. 1980 Aug 29;95 (4) :1482-8.|[2]Eyal Vardy, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86 (4) :936-946.|[3]Yuichi Ikeda, et al. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013 Dec 5;155 (6) :1323-36.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CXCR7; κ Opioid Receptor/KOR

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