ATB-343

• Description :

  ATB-343 is a derivative of Indomethacin that releases H2S. H2S has cytoprotective and anti-inflammatory effects, inhibiting leukocyte adhesion to vascular endothelium and leukocyte migration to inflammatory sites. ATB-343 can be used to suppress respiratory infections[1][2].

• CAS Number :

  [1000700-26-4]

• UNSPSC :

  12352005

• Target :

  Drug Derivative

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/atb-343.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(CC1=C(C)N(C(C2=CC=C(C=C2)Cl)=O)C3=C1C=C(C=C3)OC)OC4=CC=C(C(SS5)=CC5=S)C=C4

• Molecular Formula :

  C28H20ClNO4S3

• Molecular Weight :

  566.11

• References & Citations :

  [1]Li M, et al. Syntheses, toxicities and anti-inflammation of H2S-donors based on non-steroidal anti-inflammatory drugs. Eur J Med Chem. 2017 Sep 29;138:51-65.|[2]Methods for treating viral infections using hydrogen sulfide (H2S) donors. United States, US20160058779 A1 2016-03-03.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported