ATB-429

CAT: 0804-HY-15026Size: 1 EachDry Ice: NoHazardous: No

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Description

ATB-429, a novel H2S-releasing derivative of mesalamine, demonstrates significant anti-nociceptive and anti-inflammatory effects in models of irritable bowel syndrome (IBS) . By releasing hydrogen sulfide (H2S), ATB-429 modulates colorectal distension-induced hypersensitivity in both healthy and postcolitic rats. It attenuates abdominal withdrawal responses and suppresses spinal c-Fos mRNA expression, indicating its potential to alleviate pain associated with gastrointestinal inflammation. Moreover, ATB-429 down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA expression, effects not observed with mesalamine alone. The mechanism involves ATP-sensitive K+ (KATP) channels, as evidenced by reversal of ATB-429's effects with glibenclamide. These findings suggest ATB-429 could offer therapeutic benefits for managing painful intestinal disorders linked to inflammation[1].

CAS Number

915282-45-0

Product Name Alternative

Mesalamine-ADT

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/atb-429.html

Smiles

O=C(C1=CC(N)=CC=C1O)OC2=CC=C(C(SS3)=CC3=S)C=C2

Molecular Formula

C16H11NO3S3

Molecular Weight

361.46

References & Citations

[1]5-Amino-2-hydroxybenzoic Acid 4- (5-Thioxo-5H-[1,2]dithiol3yl) -phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T210332-01	ATB 429
B3584-100	ATB-346
MBS5802299	ATB-337
GTR17948413	ATB Antibody
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