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SDZ NKT 343

CAT: 0804-HY-108480-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108480-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SDZ NKT 343 is a selective, orally active NK1 receptor antagonist with an IC50 of 0.62 nM against human NK1 receptor. SDZ NKT 343 has good analgesic activity[1][2].
CAS Number
[180046-99-5]
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sdz-nkt-343.html
Solubility
10 mM in DMSO
Smiles
O=C(NC([C@H]1N(C(NC2=CC=CC=C2[N+]([O-])=O)=O)CCC1)=O)[C@H](CC3=CC=C4C=CC=CC4=C3)N(C)CC5=CC=CC=C5
Molecular Formula
C33H33N5O5
Molecular Weight
579.65
References & Citations
[1]Walpole CS, et al. Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist. Br J Pharmacol. 1998 May;124 (1) :83-92. |[2]Walpole C, et al. 2-Nitrophenylcarbamoyl- (S) -prolyl- (S) -3- (2-naphthyl) alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models. J Med Chem. 1998 Aug 13;41 (17) :3159-73.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
NK1R; NK2R; NK3R

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