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McN-A-343

CAT: 0804-HY-107648-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107648-01Size:5 mg
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Description
McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 produces a significant inhibitory effect on Muscarine -evoked catecholamine secretion from the isolated perfused rat adrenal gland. McN-A-343 is involved in the regulation of neuronal firing and activates enteroendocrine L cells to release glucagon-like peptide 1 (GLP-1) and modulates the secretion of α-melanocyte stimulating hormone (α-MSH) from the pituitary gland in the central nervous system. McN-A-343 reduces colonic inflammation and oxidative stress in Acetic acid (HY-Y0319) -induced ulcerative colitis (UC) mice. McN-A-343 can be used for the study of ulcerative colitis[1][2][3].
CAS Number
55-45-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mcn-a-343.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(Cl)=CC=C1)OCC#CC[N+](C)(C)C.[Cl-]
Molecular Formula
C14H18Cl2N2O2
Molecular Weight
317.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Magalhães DA, et al. McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis. Life Sci. 2021 May 1;272:119194.|[2]Wakade AR, et al. McN-A-343, a specific agonist of M1-muscarinic receptors, exerts antinicotinic and antimuscarinic effects in the rat adrenal medulla. Life Sci. 1986 Dec 1;39 (22) :2073-80. |[3]Mitchelson FJ. The pharmacology of McN-A-343. Pharmacol Ther. 2012 Aug;135 (2) :216-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1

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