AB-343

• Description:

  AB-343 is a selective covalent inhibitor of SARS-CoV-2 Mpro, with an IC50 of 8 nM and a Ki of 2.8 nM. AB-343 can effectively inhibit the main proteases of SARS-CoV-2 and many other coronaviruses, and is also active against some resistant variants. AB-343 can be used in the research of treating coronavirus infection-related diseases[1][2].

• UNSPSC:

  12352005

• Target:

  SARS-CoV; Virus Protease

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Smiles:

  O=C([C@H](NC(C(F)(F)F)=O)CC1CCC1)N2[C@H]3CC[C@@H]([C@H]2C(N[C@H](C#N)C[C@H]4CC(C)(NC4=O)C)=O)C(F)(F)C3

• Molecular Formula:

  C26H34F5N5O4

• Molecular Weight:

  575.57

• References & Citations:

  [1]McGovern-Gooch KR, et al. Biological characterization of AB-343, a novel and potent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity. Antiviral Res. 2024 Dec;232:106038.|[2]Mason J D, et al. Development of a Scalable Manufacturing Process for AB-343 Drug Substance: A Potential Candidate for the Treatment of Coronavirus Infections. Organic Process Research & Development, 2025.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3077209-48-1