PROTAC α-synuclein degrader 6

PROTAC α-synuclein degrader 6

• CAS Number: 3032208-24-2
• UNSPSC Description: PROTAC α-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with EC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-synuclein degrader 6 plays an important role in neurodegenerative diseases (NDs) research (Blue:ubiquitin E3 ligase cereblon ligand (HY-14658), Black: linker (HY-128803); Pink: Ligand for target protein (HY-151035))[1].
• Target Antigen: PROTACs; Tau Protein; α-synuclein
• Type: Reference compound
• Related Pathways: Neuronal Signaling;PROTAC
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/protac-α-synuclein-degrader-6.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC4=CC=C(C(S5)=NC6=C5C=C(C)C=C6)C=C4)=O)=C3C1=O
• Molecular Weight: 729.80
• References & Citations: [1]Wentao Zhu, et al. Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates. J Med Chem. 2024 Feb 14.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported