PROTAC α-synuclein degrader 5

PROTAC α-synuclein degrader 5

• CAS Number: 2781922-42-5
• UNSPSC Description: PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research[1].
• Target Antigen: PROTACs; α-synuclein
• Type: Reference compound
• Related Pathways: Neuronal Signaling;PROTAC
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/protac-α-synuclein-degrader-5.html
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)CNC4=CC(C5=CC(C6=CC7=C(C=C6)OCO7)=NN5)=CC=C4
• Molecular Weight: 767.78
• References & Citations: [1]Yichen Tong, et.al. Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates. Journal of Medicinal Chemistry 2023 66 (12), 7926-7942
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported