Products for Research Use Only
RegisterLogin

Pazopanib-d3

CAT: 0804-HY-10208S2Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10208S2Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pazopanib-d3 (GW786034-d3) is deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[1].
CAS Number
1219591-97-5
Product Name Alternative
GW786034-d3
UNSPSC
12352005
Target
Autophagy; c-Kit; FGFR; Isotope-Labeled Compounds; PDGFR; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(C1=CC(NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C)C([2H])([2H])[2H])=N2)=CC=C1C)(N)=O
Molecular Formula
C21H20D3N7O2S
Molecular Weight
440.54
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82 (3) :346-50.|[3]Harris PA, et al. Discovery of 5-[[4-[ (2,3-dimethyl-2H-indazol-6-yl) methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51 (15), 4632-4640.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-10208S1Pazopanib-13C, d3
HY-12009SPazopanib-13C, d3 (hydrochloride)
HY-10208-01Pazopanib
HY-10208R-01Pazopanib (Standard)
HY-10208S-01Pazopanib-d6
HY-12009-01Pazopanib (Hydrochloride)
HY-12009R-01Pazopanib (Hydrochloride) (Standard)
HY-15398S3-01Vitamin D3-d3
HY-132348S1Granisetron-d3 (1-methyl-d3)
HY-150954SL-Methionine-d3 (S-methyl-d3) Methyl-d3-sulfonium Chloride

Alternative Products

CatalogName
AR-P01282-01Pazopanib-d3
165836Pazopanib-d3 Hydrochloride
CS-AI-00205Pazopanib-13C, d3
CS-O-06855Pazopanib-13C, d3 Hydrochloride
MBS808205-01Pazopanib

Popular Products