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Pazopanib-d6

CAT: 0804-HY-10208S-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-10208S-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pazopanib-d6 is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
CAS Number
1219592-01-4
Product Name Alternative
GW786034-d6
UNSPSC
12352005
Target
Autophagy; c-Kit; FGFR; Isotope-Labeled Compounds; PDGFR; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
98.0
Solubility
DMSO : 16 mg/mL (ultrasonic)
Smiles
CC1=CC=C(NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C([2H])([2H])[2H])C([2H])([2H])[2H])=N2)C=C1S(N)(=O)=O
Molecular Formula
C21H17D6N7O2S
Molecular Weight
443.55
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Harris PA, et al. Discovery of 5-[[4-[ (2,3-dimethyl-2H-indazol-6-yl) methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51 (15), 4632-4640.|[3]Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82 (3) :346-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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