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Pazopanib-13C, d3

CAT: 0804-HY-10208S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10208S1Size:1 mg
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Description
Pazopanib-13C, d3 is the deuterium and 13C labeled Pazopanib[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
CAS Number
1261734-88-6
Product Name Alternative
GW786034-13C, d3
UNSPSC
12352005
Target
Autophagy; c-Kit; FGFR; PDGFR; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
CC1=C2C(C=C(C=C2)N(C3=NC(NC4=CC(S(N)(=O)=O)=C(C=C4)C)=NC=C3)[13C]([2H])([2H])[2H])=NN1C
Molecular Formula
C20 13CH20D3N7O2S
Molecular Weight
441.53
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Harris PA, et al. Discovery of 5-[[4-[ (2,3-dimethyl-2H-indazol-6-yl) methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51 (15), 4632-4640.|[3]Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82 (3) :346-50.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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