PD 404182

• Description :

  PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Antibiotic; Dimethylargininase (DDAH)

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pd-404182.html

• Purity :

  98.26

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  N=C1SC2=CC=CC=C2C3=NCCCN13

• Molecular Formula :

  C11H11N3S

• Molecular Weight :

  217.29

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Ghebremariam YT, et, al. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther. 2014 Jan; 348 (1) : 69-76.|[2]Chamoun-Emanuelli AM, et, al. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob Agents Chemother. 2014; 58 (2) : 687-97.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [72596-74-8]