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Pomalidomide-5-OH

CAT: 0804-HY-123324-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123324-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].
CAS Number
1547162-41-3
Product Name Alternative
5-Hydroxy pomalidomide; CC-17368
UNSPSC
12352005
Hazard Statement
H302, H312, H361
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-5-oh.html
Purity
99.46
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3N)=O
Molecular Formula
C13H11N3O5
Molecular Weight
289.24
Precautions
H302, H312, H361
References & Citations
[1]Matthew Hoffmann, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013 Feb;71 (2) :489-501.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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