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EGFR-IN-148

CAT: 0804-HY-168469Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168469Size:1 Each
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Description
EGFR-IN-148 (compound 8c) is a potent inhibitor of EGFR , with the IC50 of 0.161 μM. EGFR-IN-148 causes G1/S arrest and markedly enhances apoptosis in HepG2 cells[1].
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(C1=CC=C(N/N=C/C2=CC3=C(NC2=O)C=CC(OC)=C3)C=C1)(N)=O
Molecular Formula
C17H16N4O4S
Molecular Weight
372.40
References & Citations
[1]Mahmoud S. Elkotamy, et al. Design, synthesis, and molecular dynamics-driven evaluation of quinoline-sulfonamide derivatives as potent and selective EGFR inhibitors with promising anti-cancer efficacy and safety profiles. Bioorganic Chemistry Available online 5 February 2025, 108247
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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