EGFR-IN-148

• Description:

  EGFR-IN-148 (compound 8c) is a potent inhibitor of EGFR , with the IC50 of 0.161 μM. EGFR-IN-148 causes G1/S arrest and markedly enhances apoptosis in HepG2 cells[1].

• UNSPSC:

  12352005

• Target:

  EGFR

• Related Pathways:

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  O=S(C1=CC=C(N/N=C/C2=CC3=C(NC2=O)C=CC(OC)=C3)C=C1)(N)=O

• Molecular Formula:

  C17H16N4O4S

• Molecular Weight:

  372.40

• References & Citations:

  [1]Mahmoud S. Elkotamy, et al. Design, synthesis, and molecular dynamics-driven evaluation of quinoline-sulfonamide derivatives as potent and selective EGFR inhibitors with promising anti-cancer efficacy and safety profiles. Bioorganic Chemistry Available online 5 February 2025, 108247

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported