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Disopyramide (hydrochloride)

CAT: 0804-HY-12533BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12533BSize:1 Each
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Description
Disopyramide hydrochloride is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide hydrochloride blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide hydrochloride inhibits HERG encoded potassium channels. Disopyramide hydrochloride also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3].
CAS Number
54687-36-4
Product Name Alternative
Dicorantil (hydrochloride) ; SC-7031 (hydrochloride)
UNSPSC
12352005
Target
Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/disopyramide-hydrochloride.html
Smiles
NC(C(C1=CC=CC=C1)(C2=CC=CC=N2)CCN(C(C)C)C(C)C)=O.Cl
Molecular Formula
C21H30ClN3O
Molecular Weight
375.94
References & Citations
[1]L A Siddoway, et al. Clinical Pharmacokinetics of Disopyramide. Clin Pharmacokinet. May-Jun 1986;11 (3) :214-22.|[2]A A Paul, et al. Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide. Biochem Biophys Res Commun. 2001 Feb 9;280 (5) :1243-50.|[3]S V Jones, et al. Non-competitive Effects of Disopyramide at the Neuromuscular Junction: Evidence for Endplate Ion Channel Block. Br J Anaesth. 1987 Jun;59 (6) :776-83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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