Disopyramide

CAT: 0804-HY-12533-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12533-01Size:5 mg
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AVAILABILITY: InStock
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Description
Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3].
CAS Number
[3737-09-5]
Product Name Alternative
Dicorantil; SC-7031
UNSPSC
12352005
Hazard Statement
H302, H360
Target
Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/disopyramide.html
Concentration
10mM
Purity
99.69
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
NC(C(C1=CC=CC=C1)(C2=CC=CC=N2)CCN(C(C)C)C(C)C)=O
Molecular Formula
C21H29N3O
Molecular Weight
339.47
Precautions
H302, H360
References & Citations
[1]L A Siddoway, et al. Clinical Pharmacokinetics of Disopyramide. Clin Pharmacokinet. May-Jun 1986;11 (3) :214-22.|[2]A A Paul, et al. Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide. Biochem Biophys Res Commun. 2001 Feb 9;280 (5) :1243-50.|[3]S V Jones, et al. Non-competitive Effects of Disopyramide at the Neuromuscular Junction: Evidence for Endplate Ion Channel Block. Br J Anaesth. 1987 Jun;59 (6) :776-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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