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Disopyramide (Standard)

CAT: 0804-HY-12533RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12533RSize:1 Each
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Description
Disopyramide (Standard) is the analytical standard of Disopyramide. This product is intended for research and analytical applications. Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3].
CAS Number
3737-09-5
Product Name Alternative
Dicorantil (Standard) ; SC-7031 (Standard)
UNSPSC
12352005
Target
Potassium Channel; Reference Standards; Sodium Channel
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/disopyramide-standard.html
Smiles
NC(C(C1=CC=CC=C1)(C2=CC=CC=N2)CCN(C(C)C)C(C)C)=O
Molecular Formula
C21H29N3O
Molecular Weight
339.47
References & Citations
[1]L A Siddoway, et al. Clinical Pharmacokinetics of Disopyramide. Clin Pharmacokinet. May-Jun 1986;11 (3) :214-22.|[2]A A Paul, et al. Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide. Biochem Biophys Res Commun. 2001 Feb 9;280 (5) :1243-50.|[3]S V Jones, et al. Non-competitive Effects of Disopyramide at the Neuromuscular Junction: Evidence for Endplate Ion Channel Block. Br J Anaesth. 1987 Jun;59 (6) :776-83.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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