SSOe26 (sodium)

• UNSPSC Description:

  SSOe26 sodium is a 15mer antisense oligonucleotide targeting?HER4. SSOe26 sodium induces exon 26 skipping, leading to the generation of a novel mRNA transcript that excludes exon 26 (CYT2 isoform). SSOe26 sodium decreases tumour growth in mouse xenografts.

• Target Antigen:

  EGFR

• Type:

  Oligonucleotides

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ssoe26-sodium.html

• Solubility:

  10 mM in H2O

• Smiles:

  [SSOe26 (sodium)]

• References & Citations:

  [1]Nielsen TO, Sorensen S, Dagnæs-Hansen F, Kjems J, Sorensen BS. Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo. Br J Cancer. 2013;108(11):2291-2298. doi:10.1038/bjc.2013.247

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported