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Azido-PEG1-amine

CAT: 0804-HY-140212-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140212-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
464190-91-8
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg1-amine.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
[N-]=[N+]=NCCOCCN
Molecular Formula
C4H10N4O
Molecular Weight
130.15
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

N3-Peg1-CH2CH2NH2
CAS Number464190-91-8
PubChem CID23569172
IUPAC Name2-(2-azidoethoxy)ethanamine
Molecular FormulaC4H10N4O
Molecular Weight130.15
XLogP0
Topological Polar Surface Area49.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count9
Formal Charge0
Complexity98
SMILES
C(COCCN=[N+]=[N-])N
InChI
InChI=1S/C4H10N4O/c5-1-3-9-4-2-7-8-6/h1-5H2
InChIKey
JIQVRHWKIDNQLC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N3-Peg1-CH2CH2NH2
CAS: 464190-91-8
CID: 23569172
Formula: C4H10N4O
MW: 130.15
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight130.15
XLogP30
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass130.08546096
Monoisotopic Mass130.08546096
Topological Polar Surface Area49.6 Ų
Heavy Atom Count9
Formal Charge0
Complexity98.7
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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sc-496108Azido-PEG1-Amine
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MBS3613759-01Azido-PEG1-azide
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572675Azido-PEG1-acid

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