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Azido-PEG1-Boc

CAT: 0804-HY-140775-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140775-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azido-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
1374658-85-1
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg1-boc.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)CCOCCN=[N+]=[N-]
Molecular Formula
C9H17N3O3
Molecular Weight
215.25
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; PEG Linkers

Chemical Information

Tert-butyl 3-(2-azidoethoxy)propanoate
CAS Number1374658-85-1
PubChem CID59274208
IUPAC Nametert-butyl 3-(2-azidoethoxy)propanoate
Molecular FormulaC9H17N3O3
Molecular Weight215.25
XLogP1.8
Topological Polar Surface Area49.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count15
Formal Charge0
Complexity241
SMILES
CC(C)(C)OC(=O)CCOCCN=[N+]=[N-]
InChI
InChI=1S/C9H17N3O3/c1-9(2,3)15-8(13)4-6-14-7-5-11-12-10/h4-7H2,1-3H3
InChIKey
YQLWGRGAPJGNNQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tert-butyl 3-(2-azidoethoxy)propanoate
CAS: 1374658-85-1
CID: 59274208
Formula: C9H17N3O3
MW: 215.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight215.25
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass215.12699141
Monoisotopic Mass215.12699141
Topological Polar Surface Area49.9 Ų
Heavy Atom Count15
Formal Charge0
Complexity241
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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