Azido-PEG5-amine

• Description:

  Azido-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• UNSPSC:

  12352211

• Hazard Statement:

  H314

• Target:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/azido-peg5-amine.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCOCCOCCOCCOCCOCCN=[N+]=[N-]

• Molecular Formula:

  C12H26N4O5

• Molecular Weight:

  306.36

• Precautions:

  H314

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PEG Linkers

• CAS Number:

  516493-93-9