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Azido-PEG9-amine

CAT: 0804-HY-130169-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130169-01Size:50 mg
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Description
Azido-PEG9-amine is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG9-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG9-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
1207714-69-9
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg9-amine.html
Purity
98.0
Solubility
DMSO : 200 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C20H42N4O9
Molecular Weight
482.57
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee SM, et al. "Clickable" polymer-caged nanobins as a modular drug delivery platform. J Am Chem Soc. 2009 Jul 8;131 (26) :9311-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

Chemical Information

Azido-PEG9-amine
CAS Number1207714-69-9
PubChem CID59202801
IUPAC Name2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Molecular FormulaC20H42N4O9
Molecular Weight482.6
XLogP-1.1
Topological Polar Surface Area123
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count29
Heavy Atom Count33
Formal Charge0
Complexity419
SMILES
C(COCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])N
InChI
InChI=1S/C20H42N4O9/c21-1-3-25-5-7-27-9-11-29-13-15-31-17-19-33-20-18-32-16-14-30-12-10-28-8-6-26-4-2-23-24-22/h1-21H2
InChIKey
QECAUUOGHAUEDJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG9-amine
CAS: 1207714-69-9
CID: 59202801
Formula: C20H42N4O9
MW: 482.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight482.6
XLogP3-1.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count29
Exact Mass482.29517893
Monoisotopic Mass482.29517893
Topological Polar Surface Area123 Ų
Heavy Atom Count33
Formal Charge0
Complexity419
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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