ADH-6 (TFA)

CAT: 0804-HY-145785A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-145785A-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases[1].
CAS Number
[2990065-87-5]
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adh-6-tfa.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC(OCCCN)=C(NC(C2=NC(OCCCN)=C(NC(C3=NC(OCCCC)=C([N+]([O-])=O)C=C3)=O)C=C2)=O)C=C1)OC.OC(C(F)(F)F)=O
Molecular Formula
C31H37F3N8O11
Molecular Weight
754.67
References & Citations
[1]Palanikumar L, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12 (1) :3962.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-145785ADH-6
HY-P3323APhytochelatin 6 (TFA)
HY-157079ALP-6 (TFA)
HY-P3242AMad1 (6-21) (TFA)
HY-P6010A-01αvβ6-BP (TFA)
HY-P2321ATRAP-6 amide (TFA)
HY-161651A-01BRD4 ligand 6 (TFA)
HY-13541-01ADH-1
HY-169025ADH-353
HY-15701B-01ADH-503

Alternative Products

CatalogName
MBS5816403ADH-6 TFA
MBS5823124Phytochelatin 6 TFA
MF-0100247-01Pap12-6 TFA
MBS5799459TRAP-6 amide TFA
MF-0127044-01αvβ6-BP TFA
MF-0122234-01BRD4 ligand 6 TFA
MBS5823536Mad1 (6-21)(TFA)
MF-0159134-01Mad1 (6-21) (TFA)
MBS5817809PAR 4 (1-6)(TFA)
TRC-N353713-1MG6-Nitronoradrenaline TFA Salt (>85%)

Popular Products