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GTx1-15

CAT: 0804-HY-P5793Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P5793Size:1 Each
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Description
GTx1-15 is an inhibitor cystine knot (ICK) peptide that inhibits the voltage-dependent calcium channel Cav3.1 and the voltage-dependent sodium channels Nav1.3 and Nav1.7[1].
UNSPSC
12352209
Target
Calcium Channel; Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gtx1-15.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H]2C(C)C)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CCCCN)C(N[C@H]6CC7=CNC8=CC=CC=C78)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H]([C@@H](C)CC)C(N9[C@@H](CCC9)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](C(C)C)C(N[C@@H](CC%11=CC=CC=C%11)C(N)=O)=O)=O)=O)=O)NC6=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Molecular Formula
C176H271N53O45S7
Molecular Weight
4073.82
References & Citations
[1]Tadashi Kimura. Stability and Safety of Inhibitor Cystine Knot Peptide, GTx1-15, from the Tarantula Spider Grammostola rosea. Toxins (Basel) . 2021 Sep 3;13 (9) :621.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Calcium Channel; Nav1.1; Nav1.7

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