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PLK1-IN-15

CAT: 0804-HY-172880Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172880Size:1 Each
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Description
PLK1-IN-15 (Compound 7n) is a PLK1 inhibitor (IC50: 38.5 nM) . PLK1-IN-15 exhibits antiproliferative activity against HepG2, Huh7, H1299 and A549 cells (IC50: 2.03, 2.08, 4.79 and 17.11 μM, respectively) . PLK1-IN-15 induces cell cycle arrest at the G2/M phase and apoptosis, and has anticancer activity[1].
CAS Number
3068529-37-0
UNSPSC
12352211
Target
Apoptosis; Polo-like Kinase (PLK)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(OC)C1=C(SC2=C1CCCC2)NC3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3[N+]([O-])=O
Molecular Formula
C25H29N7O4S
Molecular Weight
523.61
References & Citations
[1]Ai M, et al. Design, synthesis and evaluation of novel cycloalkylthiophene-based aminopyrimidine derivatives as potent PLK1 inhibitors. Bioorg Med Chem Lett. 2025 Aug 15;124:130260.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1

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