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LDHA-IN-9

CAT: 0804-HY-168733Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168733Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDHA-IN-9 (Compound 1g) is an inhibitor for LDH-A with an IC50 of 25 nM. LDHA-IN-9 inhibits the proliferation of DLD-1 cell (GI50 of 27 μM) through apoptosis induction. LDHA-IN-9 exhibits antitumor activity in mouse model without significant toxicity (25 mg/kg) [1].
CAS Number
862719-04-8
UNSPSC
12352101
Target
Apoptosis; Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ldha-in-9.html
Smiles
BrC1=C2C(N(O)C(C(OC)=O)=C2COCCCCCC)=CC=C1
Molecular Formula
C17H22BrNO4
Molecular Weight
384.26
References & Citations
[1]Cheon SY, et al., Synthesis of 1-Hydroxy (and 1-Alkoxy, 1-Acyloxy) -1H-indoles and evaluations of their suppressive activities against tumor growth through inhibiting lactate dehydrogenase A. Eur J Med Chem. 2024 Nov 30;283:117104.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA

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