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LDHA-IN-10

CAT: 0804-HY-178461Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178461Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDHA-IN-10 (Compound HP19) is a Lactate Dehydrogenase-A (LDHA) inhibitor with an IC50 value of 5.2 μM. LDHA-IN-10 reduces lactate production and ATP levels, inhibiting the proliferation of pancreatic cancer cell line PANC-1. LDHA-IN-10 induces G1/S cell cycle arrest and promotes apoptosis. LDHA-IN-10 is promising for research of pancreatic ductal adenocarcinoma (PDAC) [1].
UNSPSC
12352005
Target
Lactate Dehydrogenase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1(C2=CC=C(C3=NC4=CC=CC=C4O3)C=C2)C)N=C(SCC5=CC=C(F)C=C5)NC1=O
Molecular Formula
C25H18FN3O3S
Molecular Weight
459.49
References & Citations
[1]Sharma H, et al. Synthesis, molecular modeling, biological and pharmacokinetic evaluation of hydroxy pyrimidinones and pyrimidinediones as novel LDHA inhibitors. Eur J Med Chem. 2025 Dec 15;300:118156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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