LDHA-IN-8

• Target:

  Dehydrogenase

• Related Pathways:

  Metabolism

• Purity:

  0.9973

• Bioactivity:

  LDHA-IN-8, a small molecule inhibitor of lactate dehydrogenase A (LDHA), inhibits the proliferation of pancreatic and lung cancer cells by inhibiting the activity of LDHA-catalyzed pyruvate in a dose-dependent manner (EC 50=14.54?M), decreasing the intracellular lactate content and increasing the intracellular reactive oxygen species (ROS) levels.

• Smiles:

  O=C1NC(=O)C(=CC=2C=C(N(C=3C=NC=CC3)C2C)C)N1

• Molecular Formula:

  C15H14N4O2

• Molecular Weight:

  282.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  347380-13-6