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LDHA-IN-8

CAT: 0804-HY-169060Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169060Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDHA-IN-8 (Compound 6) is a lactate dehydrogenase (LDHA) inhibitor. LDHA-IN-8 inhibits LDHA catalysis of pyruvate in a dose-dependent manner (EC50 value of 14.54 μM), reduces intracellular lactate levels, and increases intracellular reactive oxygen species (ROS) levels, thereby inhibiting the proliferation of pancreatic cancer cells and lung cancer cells. LDHA-IN-8 holds promise for research in the field of LDHA-related antitumor therapies[1].
UNSPSC
12352005
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ldha-in-8.html
Smiles
CC1=CC(/C=C2C(NC(N/2)=O)=O)=C(C)N1C3=CN=CC=C3
Molecular Formula
C15H14N4O2
Molecular Weight
282.30
References & Citations
[1]Shu Y, et al. Development of human lactate dehydrogenase a inhibitors: high-throughput screening, molecular dynamics simulation and enzyme activity assay. J Comput Aided Mol Des. 2024 Aug 10;38 (1) :28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA

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