DKK2 Antibody

CAT: 0800-F54135-0.05MLSize: 0.05 mLDry Ice: NoHazardous: No
CAT#:0800-F54135-0.05MLSize:0.05 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) . [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:2000
UniProt
Q9UBU2
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Recombinant human DKK2 was used as the immunogen for the DKK2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1833CT856.7.20
Applications
WB
Purity
Protein G purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the DKK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DKK2 antibody is available for research use only.
Storage Conditions
Aliquot the DKK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the DKK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of DKK2 antibody at 1:2000: Lane 1) human brain and 2) mouse heart lysate. Expected molecular weight: 28-35 kDa.

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