DKK2 Antibody

• Description :

  Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) . [UniProt]

• Specifications :

  Western blot: 1:2000

• UniProt :

  Q9UBU2

• Host :

  Mouse

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant human DKK2 was used as the immunogen for the DKK2 antibody.

• Clonality :

  Monoclonal

• Isotype :

  IgG1 k

• Clone :

  1833CT856.7.20

• Applications :

  WB

• Purity :

  Protein G purified

• Format :

  Purified

• Buffer :

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution :

  Aliquot the DKK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations :

  This DKK2 antibody is available for research use only.

• Storage Conditions :

  Aliquot the DKK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation :

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes :

  The stated application concentrations are suggested starting points. Titration of the DKK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number :

  9007-83-4

• Image Legend :

  Western blot testing of DKK2 antibody at 1:2000: Lane 1) human brain and 2) mouse heart lysate. Expected molecular weight: 28-35 kDa.