DKK2 Antibody

• Description:

  Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) . [UniProt]

• Specifications:

  Western blot: 1:2000

• UniProt:

  Q9UBU2

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant human DKK2 was used as the immunogen for the DKK2 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 k

• Clone:

  1833CT856.7.20

• Applications:

  WB

• Purity:

  Protein G purified

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the DKK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This DKK2 antibody is available for research use only.

• Storage Conditions:

  Aliquot the DKK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  The stated application concentrations are suggested starting points. Titration of the DKK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot testing of DKK2 antibody at 1:2000: Lane 1) human brain and 2) mouse heart lysate. Expected molecular weight: 28-35 kDa.