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DKK1 Antibody

CAT: 0800-F53121-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F53121-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-1:4000
UniProt
O94907
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DKK1 antibody was produced from a rabbit immunized with a recombinant protein of human DKK1.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the DKK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DKK1 antibody is available for research use only.
Storage Conditions
Aliquot the DKK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the DKK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from (1) A549, (2) HeLa, (3) HepG2, (4) Jurkat, (5) mouse NIH3T3 cell line using DKK1 antibody. Predicted molecular weight: 26-40 kDa depending on glycosylation level.

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