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Dickkopf-2 Antibody / DKK2

CAT: 0800-F54702-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54702-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The 259-amino acid DKK2 protein, like DKK1, DKK3, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cys residues each. The second cys region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart, brain, skeletal muscle, and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
Q9UBU2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 31-62 from the human protein was used as the immunogen for the Dickkopf-2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Dickkopf-2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Dickkopf-2 antibody is available for research use only.
Storage Conditions
Aliquot the Dickkopf-2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Dickkopf-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human Jurkat cell lysate with Dickkopf-2 antibody. Expected molecular weight: 28-35 kDa.

UniProtKB · Q9UBU2

Dickkopf-related protein 2

DKK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UBU2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DKK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Dickkopf-2, Dkk-2, hDkk-2
EC number
—
Processing
Precursor
Secondary accessions
A0AVE9, B2R6S7, Q9UIU3
Protein keywords

Molecular function

Developmental protein

PTM

Disulfide bondGlycoprotein

Technical term

Proteomics identificationReference proteome

Cellular component

Secreted

Domain

Signal

Biological process

Wnt signaling pathway

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