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J147

CAT: 0804-HY-13779A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13779A-01Size:1 mg
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Description
J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB) . J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD) [1].
CAS Number
1807913-16-1
UNSPSC
12352005
Target
Dopamine Transporter; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological disease
Assay Protocol
https://www.medchemexpress.com/j147.html
Purity
99.90
Solubility
DMSO : 40 mg/mL (ultrasonic; warming)
Smiles
COC1=CC=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=C1
Molecular Formula
C18H17F3N2O2
Molecular Weight
350.33
References & Citations
[1]Kyoungdo Kim, et al. Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity. Org Biomol Chem. 2015 Oct 7;13 (37) :9564-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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