J147

• Description :

  J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB) . J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD) [1].

• UNSPSC :

  12352005

• Target :

  Dopamine Transporter; Monoamine Oxidase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological disease

• Assay Protocol :

  https://www.medchemexpress.com/j147.html

• Purity :

  99.90

• Solubility :

  DMSO : 40 mg/mL (ultrasonic; warming)

• Smiles :

  COC1=CC=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=C1

• Molecular Formula :

  C18H17F3N2O2

• Molecular Weight :

  350.33

• References & Citations :

  [1]Kyoungdo Kim, et al. Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity. Org Biomol Chem. 2015 Oct 7;13 (37) :9564-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [1807913-16-1]