J147

• Description:

  J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB) . J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD) [1].

• UNSPSC:

  12352005

• Target:

  Dopamine Transporter; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological disease

• Assay Protocol:

  https://www.medchemexpress.com/j147.html

• Purity:

  99.90

• Solubility:

  DMSO : 40 mg/mL (ultrasonic; warming)

• Smiles:

  COC1=CC=CC (/C=N/N (C2=C (C=C (C=C2) C) C) C (C (F) (F) F) =O) =C1

• Molecular Formula:

  C18H17F3N2O2

• Molecular Weight:

  350.33

• References & Citations:

  [1]Kyoungdo Kim, et al. Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity. Org Biomol Chem. 2015 Oct 7;13 (37) :9564-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  1807913-16-1