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J147

CAT: 0804-HY-13779A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13779A-01Size:1 mg
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Description
J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB) . J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD) [1].
CAS Number
1807913-16-1
UNSPSC
12352005
Target
Dopamine Transporter; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological disease
Assay Protocol
https://www.medchemexpress.com/j147.html
Purity
99.90
Solubility
DMSO : 40 mg/mL (ultrasonic; warming)
Smiles
COC1=CC=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=C1
Molecular Formula
C18H17F3N2O2
Molecular Weight
350.33
References & Citations
[1]Kyoungdo Kim, et al. Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity. Org Biomol Chem. 2015 Oct 7;13 (37) :9564-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Chemical Information

J147

J147 is an anilide.

CAS Number1807913-16-1
PubChem CID25229652
IUPAC NameN-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide
Molecular FormulaC18H17F3N2O2
Molecular Weight350.3
XLogP4.7
Topological Polar Surface Area41.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity481
SMILES
CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)/N=C/C2=CC(=CC=C2)OC)C
InChI
InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
InChIKey
HYMZAYGFKNNHDN-SSDVNMTOSA-N
Chemical Structure
2D Structure
2D structure of J147
CAS: 1807913-16-1
CID: 25229652
Formula: C18H17F3N2O2
MW: 350.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight350.3
XLogP34.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass350.12421228
Monoisotopic Mass350.12421228
Topological Polar Surface Area41.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity481
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
HY-135008-01J14

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CatalogName
522384J147
A15953-50J147 50mg
A15953-100J147 100mg
A15953-500J147 500mg
A15953-5J147 5mg
A15953-25J147 25mg
A15953-10J147 10mg
A15953-10mM-DJ147 10mM * 1mL in DMSO
bs-60012C-01J147 --- Neuroprotective Small Molecule

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