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RecombinantEndostatin, Human

CAT: 0384-BK0337-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0384-BK0337-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
CAS Number
9000-83-3
Endotoxin
Endotoxin level is less than 0.1 ng per μg (1EU/μg) of Endostatin.
Purity
Greater than 97% by SDS-PAGE
Bioactivity
Determined by Endothelial Cell Tube Formation. The cells treated with 10μ g/ml Endostatin showed significant anti-angiogenesis effect.
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
~20.2 kDa, observed by reducing SDS-PAGE.
Storage Conditions
The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20°C. For the first use, reconstitute in water, aliquot and store at -20°C to avoid multiple freeze-thaws.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.
Host or Source
P. pastoris
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
AH SHRDFQPVLH LVALNSPLSG GMRGIRGADF QCFQQARAVG LAGTFRAFLS SRLQDLYSIV RRADRAAVPI VNLKDELLFP SWEALFSGSE GPLKPGARIF SFDGKDVLRH PTWPQKSVWH GSDPNGRRLT ESYCETWRTE APSATGQASS LLGGRLLGQS AASCHHAYIV LCIENSFMTA SK

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