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RecombinantEndostatin, Human

CAT: 0013-GTR18990205-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18990205-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Product Name Alternative
Endostatin
Source
P. pastoris
Endotoxin
Endotoxin level is less than 0.1 ng per μg (1EU/μg) of Endostatin.
Purity
Greater than 97% by SDS-PAGE
Bioactivity
Determined by Endothelial Cell Tube Formation. The cells treated with 10μg/ml Endostatin showed significant anti-angiogenesis effect.
Form
The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.
Molecular Weight
~20.2 kDa, observed by reducing SDS-PAGE.
Storage Conditions
The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20°C. For the first use, reconstitute in water, aliquot and store at -20°C to avoid multiple freeze-thaws.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O or PBS at 100 μg/ml.
Preservative
The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.
AA Sequence
AH SHRDFQPVLH LVALNSPLSG GMRGIRGADF QCFQQARAVG LAGTFRAFLS SRLQDLYSIV RRADRAAVPI VNLKDELLFP SWEALFSGSE GPLKPGARIF SFDGKDVLRH PTWPQKSVWH GSDPNGRRLT ESYCETWRTE APSATGQASS LLGGRLLGQS AASCHHAYIV LCIENSFMTA SK

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