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RecombinantIFN-γ, Rat

CAT: 0384-BK0082-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0384-BK0082-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interferon gamma (IFN-γ), also known as Type II interferon, is a cytokine produced primarily by T-lymphocytes and natural killer cells. The active form of IFN-γ is an antiparallel dimer that interacts with the receptor IFN-γR1 and activates the IFN-γ/JAK/STAT pathway. IFN-γ signaling promotesbiological functions primarily related to antiviral and antibacterial defense, apoptosis, inflammation, and regulation of innate and acquired immune responses. While IFN-γ–induced inflammatory cascades summon a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-γ is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.Recombinant Rat Interferon gamma (IFN-γ) produced in E.coli is a single non-glycosylated polypeptide chain containing 134 amino acids. A fully biologically active molecule, rrIFN-γ has a molecular mass of 15.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Bioactivity
ED50 <0.5 ng/ml, measured by cytotoxicity assay using WEHI-279 cells, corresponding to a specific activity of >2x10ˆ6 units/mg.
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
15.5 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant Rat IFN-γ remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, recombinant Rat IFN-γ should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
GT LIESLESLKN YFNSSSMDAM EGKSLLLDIW RNWQKDGNTK ILESQIISFY LRLFEVLKDN QAISNNISVI ESHLITNFFS NSKAKKDAFM SIAKFEVNNP QIQHKAVNEL IRVIHQLSPE SSLRKRKRSR C

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