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RecombinantGM-CSF, Human

CAT: 0384-BK0066-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0384-BK0066-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human Granulocyte Macrophage Colony Stimulating Factor (hGM-CSF), a hematopoietic growth factor, is mainly involved in granulopoiesis and monocytopoiesis. It is produced by T-cells and macrophages in response to antigens, and by endothelial cells and fibroblasts following induction of variouscytokines [1]. A monomeric protein of 127 amino acidswith six glycosylation sites and two intra disulfide bonds [2,3], glycosylated and non-glycosylated hGM-CSFs show similar biological activities [4].Other than its connection to the growth and development of granulocytes and macrophages, it is also indispensable for the proliferation of erythroid and megakaryocytic cells [5].Recombinant human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF) produced in E.coli is a non-glycosylated polypeptide. A fully biologically active molecule, rhGM-CSF has a molecular mass of 14 kDa analyzed by SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
<1 EU/μg, determined by LAL method.
Purity
>95 % as analyzed by SDS-PAGE.
Bioactivity
ED50 < 0.5 ng/ml, measured by proliferation assay of TF-1 cells, corresponding to a specific activity of >2.0 x 10ˆ6units/mg
Reconstitution
Reconstituted in ddH2O at 100 μg/ml.
Molecular Weight
14 kDa, observed by SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF) remains stable up to 12 months at -80°C from date of receipt. Upon reconstitution, rhGM-CSF should be stable up to 4 weeks at 4°C or up to 6 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against 10 mM PB, pH7.0.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
MAPARSPSP STQPWEHVNA IQEARRLLNL SRDTAAEMNE TVEVISEMFD LQEPTCLQTR LELYKQGLRG SLTKLKGPLT MMASHYKQHC PPTPETSCAT QIITFESFKE NLKDFLLVIP FDCWEPVQE

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