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RecombinantGM-CSF, Human

CAT: 0013-GTR18991657-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18991657-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human Granulocyte Macrophage Colony Stimulating Factor (hGM-CSF), a hematopoietic growth factor, is mainly involved in granulopoiesis and monocytopoiesis. It is produced by T-cells and macrophages in response to antigens, and by endothelial cells and fibroblasts following induction of variouscytokines [1]. A monomeric protein of 127 amino acidswith six glycosylation sites and two intra disulfide bonds [2,3], glycosylated and non-glycosylated hGM-CSFs show similar biological activities [4].Other than its connection to the growth and development of granulocytes and macrophages, it is also indispensable for the proliferation of erythroid and megakaryocytic cells [5].Recombinant human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF) produced in E.coli is a non-glycosylated polypeptide. A fully biologically active molecule, rhGM-CSF has a molecular mass of 14 kDa analyzed by SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.
Product Name Alternative
Granulocyte Macrophage Colony Stimulating Factor, CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, Molgramostin, Sargramostim
Source
Escherichia coli.
Field of Research
Immunology & Inflammation
Endotoxin
< 1 EU/μg, determined by LAL method.
Purity
>95 % as analyzed by SDS-PAGE.
Bioactivity
ED50 2.0 x 10ˆ6units/mg
Form
Lyophilized after extensive dialysis against 10 mM PB, pH 7.0.
Molecular Weight
14 kDa, observed by SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF) remains stable up to 12 months at -80°C from date of receipt. Upon reconstitution, rhGM-CSF should be stable up to 4 weeks at 4°C or up to 6 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against 10 mM PB, pH 7.0.
AA Sequence
MAPARSPSP STQPWEHVNA IQEARRLLNL SRDTAAEMNE TVEVISEMFD LQEPTCLQTR LELYKQGLRG SLTKLKGPLT MMASHYKQHC PPTPETSCAT QIITFESFKE NLKDFLLVIP FDCWEPVQE

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