NR2E1 polyclonal antibody

CAT: 0384-BS8915-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS8915-01Size:50 µL
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Background
NR2 proteins are a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E1 (nuclear receptor subfamily 2, group E, member 1), also known as TLX, is an essential component in the formation of synaptic plasticity and dendritic structure in retinal astrocytes. In addition, NR2E1 is a orphan receptor that binds DNA as part of the hormone response element (HRE), a transcription regulator for hormones. DNA-binding orphan receptors have the conserved sequence 5'-AAGGTCA-3', a motif that determines substrate binding specificity. NR2E1 is expressed in brain tissue, with highest levels in astrocytes, and is localized to the nucleus.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Protein tailless homolog; Tll; hTll; NR2E1; TLX
Swiss Prot
Q9Y466
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human NR2E1.
Conjugation
Unconjugated
Applications
WB IF IP
Dilution
WB 1:500 - 1:2000 IF 1:50 - 1:100 IP 1:50 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 43kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
NR2E1 polyclonal antibody detects endogenous levels of NR2E1 protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using NR2E1 antibody.
Host or Source
Rabbit

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