TPH2 polyclonal antibody

• Background :

  This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2; TPH2; NTPH

• Swiss Prot :

  Q8IWU9

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant full length Human TPH2.

• Conjugation :

  Unconjugated

• Applications :

  WB IHC IF

• Dilution :

  WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 56kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  TPH2 polyclonal antibody detects endogenous levels of TPH2 protein.

• Applications Notes :

  Immunofluorescence analysis of A549 cell using TPH2 antibody. Blue: DAPI for nuclear staining.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4