FTβ (E285) polyclonal antibody

CAT: 0384-BS3377-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS3377-01Size:50 µL
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Background
Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an a-b heterodimer. The β subunit, which is known as FTβ, CAAX farnesyltransferase subunit β, or Ras proteins prenyltransferase subunit β, is a 437 amino acid protein that contains five PFTB repeats and binds the peptide substrate. The α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Protein farnesyltransferase subunit beta; FTase-beta; FTase-β; FTase β; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta; FNTB
Swiss Prot
P49356
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 250-300 of Human FTβ.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 48 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
FTβ (E285) polyclonal antibody detects endogenous levels of FTβ protein.
Applications Notes
Western blot (WB) analysis of FTβ (E285) pAb at 1:500 dilution Lane1:A549 whole cell lysate (40ug) Lane2:PC3 whole cell lysate (40ug) Lane3:MCF-7 whole cell lysate (40ug) Lane4:SGC7901 whole cell lysate (40ug) Lane5:L02 whole cell lysate (40ug)
Host or Source
Rabbit

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