WASP (E284) polyclonal antibody

CAT: 0384-BS1607-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS1607-01Size:50 µL
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Background
The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that has been mapped to the short arm of the X chromosome at Xp11.23. WAS is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative disease. The gene that is mutated in the syndrome encodes a 53 kDa proline-rich protein of unknown function designated WAS protein (WASP) . A clue to WASP function came from the observation that T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeleton suggesting the involvement of WASP in cytoskeletal organization. Close examination of the WASP sequence revealed a putative Cdc42/Rac interacting domain, homologous with those found in PAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector of Cdc42.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
IMD2; SCNX; THC; THC1; Thrombocytopenia 1 (X linked) ; U42471; Was; WASp; WASP; Wiskott Aldrich syndrome (eczema thrombocytopenia) ; Wiskott Aldrich syndrome protein; Wiskott-Aldrich syndrome protein
Swiss Prot
P42768
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to amino acids 250-300 of Human WASP.
Conjugation
Unconjugated
Related Pathways
Regulation of Actin Dynamics, Contribution of ECM and Cytoskeletal Factors to EMT, Adherens Junction signaling
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 53 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
WASP (E284) polyclonal antibody detects endogenous levels of WASP protein.
Host or Source
Rabbit

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