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TLK1 polyclonal antibody

CAT: 0384-BS62542-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS62542-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Tousled-like kinases (TLK1 and TLK2, also designated PKU-β and PKU-α, respectively) are the human homologs of the Tousled gene from Arabidopsis thaliana, which encodes a Serine/Threonine kinase that is necessary for proper organ morphogenesis. Both TLKs contain a nuclear localization signal and a predicted coiled-coil region in the N-terminal domain. TLK is ubiquitously expressed, and is prevalent in mouse testis, especially in pachytene spermatocytes and round spermatids. It displays a propensity to dimerize through an interaction between its coiled-coil structure and is able to autophosphorylate, as well as phosphorylate exogenous substrates. TLK1 and TLK2 are regulated by the cell cycle, showing maximum activity during S phase. Subsequently, they are thought to regulate the development of multicellular organisms, including playing a key role in spermatogenesis, through a series of phosphorylations.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Serine/threonine-protein kinase tousled-like 1; PKU-beta; Tousled-like kinase 1; TLK-1; KIAA0137; PKU-β; PKU β; PKUβ
Swiss Prot
Q9UKI8
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human TLK1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 87 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TLK1 polyclonal antibody detects endogenous levels of TLK1 protein.
Applications Notes
Western blot (WB) analysis of TLK1 polyclonal antibody at 1:500 dilution LaneA:HepG2 whole cell lysate LaneB:AML-12 whole cell lysate
Host or Source
Rabbit

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