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OAZ1 polyclonal antibody

CAT: 0384-BS65128-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS65128-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ornithine decarboxylase antizyme 1 (OAZ1) Homo sapiens The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Product Name Alternative
OAZ1; OAZ; Ornithine decarboxylase antizyme 1; ODC-Az
Swiss Prot
P54368
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63
Conjugation
Unconjugated
Applications
IHC-p, IF (paraffin section), ELISA
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Modification
Unmodification
Molecular Weight
/
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
AZ1 Polyclonal Antibody detects endogenous levels of AZ1 protein.
Applications Notes
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using OAZ1 Antibody. The picture on the right is blocked with the synthesized peptide.
Host or Source
Rabbit

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