DM-PIT-1

DM-PIT-1

• Product Name Alternative: 3,5-Dimethyl PIT-1
• CAS Number: 701947-53-7
• UNSPSC Description: DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer[1][2].
• Target Antigen: Apoptosis; PI3K
• Type: Reference compound
• Related Pathways: Apoptosis;PI3K/Akt/mTOR
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dm-pit-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC(C)=CC(C)=C1)NC(NC2=C(C=CC([N+]([O-])=O)=C2)O)=S
• Molecular Weight: 345.37
• References & Citations: [1]Riehle RD, et al. Micellar formulations of pro-apoptotic DM-PIT-1 analogs and TRAIL in vitro and in vivo. Drug Deliv. 2013 Feb;20(2):78-85. |[2]Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported