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DM-PIT-1

CAT: 0804-HY-124348-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-124348-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer[1][2].
CAS Number
[701947-53-7]
Product Name Alternative
3,5-Dimethyl PIT-1
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dm-pit-1.html
Purity
99.9
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C)=CC(C)=C1)NC(NC2=C(C=CC([N+]([O-])=O)=C2)O)=S
Molecular Formula
C16H15N3O4S
Molecular Weight
345.37
References & Citations
[1]Riehle RD, et al. Micellar formulations of pro-apoptotic DM-PIT-1 analogs and TRAIL in vitro and in vivo. Drug Deliv. 2013 Feb;20 (2) :78-85. |[2]Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107 (46) :20126-31.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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