PIT-1 (Standard)

• Description :

  PIT-1 (Standard) is the analytical standard of PIT-1. This product is intended for research and analytical applications. PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1].

• UNSPSC :

  12352005

• Target :

  PI3K; Reference Standards

• Related Pathways :

  Others; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Smiles :

  O=C(NC(NC1=CC([N+]([O-])=O)=CC(Cl)=C1O)=S)C2=CC=CC=C2

• Molecular Formula :

  C14H10ClN3O4S

• Molecular Weight :

  351.76

• References & Citations :

  [1]Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107 (46) :20126-31.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [53501-41-0]