Metaxalone-d6

CAT: 0804-HY-B0678S1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0678S1Size:1 mg
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Description
Metaxalone-d6 is deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia[1][2][3].
CAS Number
[1189944-95-3]
Product Name Alternative
AHR438-d6; NSC170959-d6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Isotope-Labeled Compounds; NF-κB; PGC-1α
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; NF-κB; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C1=CC(C([2H])([2H])[2H])=CC(OCC2OC(NC2)=O)=C1
Molecular Formula
C12H9D6NO3
Molecular Weight
227.29
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Pallio G, et al. MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells. Int J Mol Sci. 2021;22 (16) :8425. |[3]Stanko JR. Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner. Cranio. 1990 Jul;8 (3) :234-43.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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