Metaxalone

• Description:

  Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia[1][2].

• Product Name Alternative:

  AHR438; NSC170959

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  NF-κB; PGC-1α

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; NF-κB

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Metaxalone.html

• Concentration:

  10mM

• Purity:

  99.95

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C1OC(COC2=CC(C)=CC(C)=C2)CN1

• Molecular Formula:

  C12H15NO3

• Molecular Weight:

  221.26

• Precautions:

  H302

• References & Citations:

  [1]Pallio G, D'Ascola A, Cardia L, et al. MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells. Int J Mol Sci. 2021;22 (16) :8425. |[2]Stanko JR. Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner. Cranio. 1990 Jul;8 (3) :234-43.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [1665-48-1]