Products for Research Use Only
RegisterLogin

Metaxalone

CAT: 0804-HY-B0678-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0678-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia[1][2].
CAS Number
1665-48-1
Product Name Alternative
AHR438; NSC170959
UNSPSC
12352005
Hazard Statement
H302
Target
NF-κB; PGC-1α
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Metaxalone.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1OC(COC2=CC(C)=CC(C)=C2)CN1
Molecular Formula
C12H15NO3
Molecular Weight
221.26
Precautions
H302
References & Citations
[1]Pallio G, D'Ascola A, Cardia L, et al. MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells. Int J Mol Sci. 2021;22 (16) :8425. |[2]Stanko JR. Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner. Cranio. 1990 Jul;8 (3) :234-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
T1610-01Metaxalone
CS-O-06760Metaxalone-d3
T71285Metaxalone-d6

Popular Products