Products for Research Use Only
RegisterLogin

Licofelone-d6

CAT: 0804-HY-B1452S1Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1452S1Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Licofelone-d6 is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].
CAS Number
1178549-81-9
Product Name Alternative
ML-3000-d6
UNSPSC
12352005
Target
Apoptosis; COX; Lipoxygenase
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
OC(CC1=C(C2=CC=C(C=C2)Cl)C(C3=CC=CC=C3)=C4N1CC(C([2H])([2H])[2H])(C4)C([2H])([2H])[2H])=O
Molecular Formula
C23H16D6ClNO2
Molecular Weight
385.92
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29 (2) :371-80.|[3]Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford) . 2004 Feb43 Suppl 1:i21-5.|[4]Laufer SA, et al. (6,7-Diaryldihydropyrrolizin-5-yl) acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Med Chem. 1994 Jun 1037 (12) :1894-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B1452-01Licofelone
HY-B1452R-01Licofelone (Standard)
HY-110225-01Levetiracetam-d6 (ring-d6)
HY-N0893STetrahydrocurcumin-d6
HY-W750155Tetramethrin-d6
HY-W744578Taurolidine-d6
HY-W744275Tipelukast-d6
HY-W704964-01Dimethylcyanamide-d6
HY-W010201SCitronellol-d6
HY-N0709S1Coumarin-d6

Alternative Products

CatalogName
B1448-5Licofelone
A11697-50Licofelone 50mg
A11697-10Licofelone 10mg
C08299-5mgLicofelone (ML3000)
PXB42704-01Licofelone-d4
A11697-200Licofelone 200mg
A11697-100Licofelone 100mg
A11697-500Licofelone 500mg

Popular Products